The 2022 NXT Roadblock was the third Roadblock professional wrestling event produced by WWE. It was held primarily for wrestlers from the NXT brand division. Unlike the previous two Roadblock events, NXT Roadblock aired as a special episode of NXT on the USA Network. The television special took place on March 8, 2022, at the WWE Performance Center in Orlando, Florida. The event's title is a reference to its position on the road to NXT Stand & Deliver, NXT's WrestleMania week event. This was the first Roadblock event since Roadblock: End of the Line in December 2016.

The WWE Performance Center is the official professional wrestling school system of the American organization, WWE, a division of TKO Group Holdings, a subsidiary of Endeavor Group Holdings. The system currently operates two Performance Center locations, which serve as training facilities for WWE wrestlers, as well as sports science and medical facilities. The first branch, located in Orlando, Florida, was opened on July 11, 2013. The second branch opened on January 11, 2019, in Enfield, London.