The sixth season of NYPD Blue premiered on ABC on October 20, 1998, and concluded on May 25, 1999.

NYPD Blue is an American police procedural television series set in New York City, exploring the struggles of the fictional 15th Precinct detective squad in Manhattan. Each episode typically intertwines several plots involving an ensemble cast. The show was created by Steven Bochco and David Milch, and was inspired by Milch's relationship with Bill Clark, a former member of the New York City Police Department who eventually became one of the show's producers. The series was originally broadcast by ABC from September 21, 1993‚ to March 1, 2005. It was ABC's longest-running primetime one-hour drama series until Grey's Anatomy surpassed it in 2016.