The Nagasaki Main Line , or simply Nagasaki Line, is a railway line owned by the Kyushu Railway Company connecting Tosu Station in Saga Prefecture to Nagasaki Station in Nagasaki Prefecture, Japan. There is a separate branch of this line from Kikitsu Station to Urakami Station by way of Nagayo Station and the Nagasaki Tunnel, avoiding a long detour.

Nagasaki Station is a railway station in Nagasaki, Nagasaki Prefecture, Japan, operated by the Kyushu Railway Company. It is the terminus of the Nishi Kyushu Shinkansen and the Nagasaki Main Line.