The Nanbu clan was a Japanese samurai clan who ruled most of northeastern Honshū in the Tōhoku region of Japan for over 700 years, from the Kamakura period through the Meiji Restoration of 1868. The Nanbu claimed descent from the Seiwa Genji of Kai Province and were thus related to the Takeda clan. The clan moved its seat from Kai to Mutsu Province in the early Muromachi period, and were confirmed as daimyō of Morioka Domain under the Edo-period Tokugawa shogunate. The domain was in constant conflict with neighboring Hirosaki Domain, whose ruling Tsugaru clan were once Nanbu retainers.

This is a list of Japanese clans. The old clans (gōzoku) mentioned in the Nihon Shoki and Kojiki lost their political power before the Heian period, during which new aristocracies and families, kuge, emerged in their place. After the Heian period, the samurai warrior clans gradually increased in importance and power until they came to dominate the country after the founding of the first shogunate.