The Nanjing–Anqing intercity railway is a high-speed rail, passenger-dedicated line between cities of Nanjing, Jiangsu Province and Anqing, Anhui Province, in China. Construction of the 258-kilometre (160 mi) railway began in January 2010, and the line was opened on 6 December 2015.

Anqing is a prefecture-level city in the southwest of Anhui province, People's Republic of China. Its population was 4,165,284 as of the 2020 census, with 804,493 living in the built-up area made up of three urban districts. Anqing is famous as the birthplace of Chen Duxiu, one of the founding fathers of the Chinese Communist Party, who served as the first General Secretary of the Chinese Communist Party from 1921 to 1928. Huangmei opera, a renowned Chinese opera style, originated in the city of Anqing. This captivating art form gained immense popularity since the 1950s, largely attributed to the exceptional talents of local actors and actresses from Anqing. Huangmei opera is a significant cultural treasure that defines the rich heritage of the city of Anqing.