The Nanjing World Challenge is a track and field meet at Nanjing Olympic Sports Centre in Nanjing, China. The inaugural edition was held in 2019 as part of the IAAF World Challenge.

The IAAF World Challenge was an annual, global circuit of one-day track and field competitions organized by the International Association of Athletics Federations (IAAF). First held in 2010, it replaced the IAAF Grand Prix and IAAF Super Grand Prix series to form the second tier of international one-day meetings, after the IAAF Diamond League. Unlike the Diamond League, the IAAF World Challenge comprised stand-alone meetings, and no overall winners are crowned. The series was made defunct at the end of 2019 and was replaced by the World Athletics Continental Tour, which includes series winners for non-Diamond League events.