Nanticoke Creek is a tributary of the Susquehanna River in Luzerne County, Pennsylvania, in the United States. It is approximately 4.4 miles (7.1 km) long and flows through Hanover Township and Nanticoke. The watershed of the creek has an area of 7.57 square miles (19.6 km2). The creek has one named tributary, which is known as Espy Run. Nanticoke Creek impaired by pH and metals due to abandoned mine drainage. Abandoned mine drainage discharges in the creek's watershed include the Truesdale Mine Discharge and the Askam Borehole. The creek is located in the Northern Middle Anthracite Field and is in the Anthracite Valley Section of the ridge and valley physiographic province. The main rock formations in the watershed include the Mauch Chunk Formation, the Pottsville Group, and the Llewellyn Formation. The surficial geology consists of coal dumps, surface mining land, alluvium, Wisconsinan Outwash, Wisconsinan Till, urban land, and bedrock.

Hanover Township is a township in Luzerne County, Pennsylvania. As of the 2020 census, the population was 11,424, making it the most populous township in the county.