The Nanticoke River is a tributary of the Chesapeake Bay on the Delmarva Peninsula. It rises in southern Kent County, Delaware, flows through Sussex County, Delaware, and forms the boundary between Dorchester County, Maryland and Wicomico County, Maryland. The tidal river course proceeds southwest into the Tangier Sound, Chesapeake Bay. The river is 64.3 miles (103.5 km) long. A 26-mile ecotourism water trail running along the River was set aside in July 2011 by Delaware state and federal officials, contiguous with a 37-mile water-trail extending through Maryland to the Chesapeake Bay.

Vienna is a town in Dorchester County, Maryland, United States. The population was 271 at the 2010 census.