Napoli Centrale is the main railway station in the city of Naples and in southern Italy and the sixth largest station in Italy in terms of passenger flow with an annual ridership of 50 million. It is located next to Piazza Garibaldi to the east of the old city. It is the primary rail terminus and station for Naples, and serves Trenitalia national railways and EAV. This one has an underground section known as Stazione di Napoli Piazza Garibaldi, which is served by the metropolitan trains of the line 2, line 1 (Garibaldi), and 3, 12, 14, and 15 EAV Circumvesuviana lines which is accessible from 2 entrances inside the Centrale station, 1 outside in glass, and from the new Garibaldi Square.

The Rome–Naples high-speed railway line is one of the railways in the Italian high-speed rail network. Initially opened in December 2005, it is the first railway line in Italy to be electrified at 25 kV AC and the first in the world to use ETCS Level 2 in normal rail operations.