The Nashville metropolitan area is a metropolitan statistical area in north-central Tennessee. Its principal city is Nashville, the capital of and largest city in Tennessee. With a population of over 2 million, it is the most populous metropolitan area in Tennessee. It is also the largest metropolitan area in Tennessee in terms of land area.

Interstate 65 (I-65) is part of the Interstate Highway System that runs 887.30 miles (1,427.97 km) north–south from Mobile, Alabama, to Gary, Indiana. In Tennessee, I-65 traverses the middle portion of the state, running from Ardmore at the Alabama border to the Kentucky border near Portland. The route serves the state capital and largest city of Nashville, along with many of its suburbs. Outside of urban areas, the Interstate bypasses most cities and towns that it serves, instead providing access via state and U.S. Highways. The Interstate passes through the Highland Rim and Nashville Basin physiographic regions of Tennessee, and is often used as the dividing line between the eastern and western portions of the former.