The Natchez Trace Parkway is a limited-access national parkway in the Southeastern United States that commemorates the historic Natchez Trace and preserves sections of that original trail. Its central feature is a two-lane road that extends 444 miles (715 km) from Natchez, Mississippi, to Nashville, Tennessee. Access to the parkway is limited, with more than 50 access points in Mississippi, Alabama, and Tennessee. The southern end of the route is in Natchez at its intersection with Liberty Road, and the northern end is northeast of Fairview, Tennessee, in the suburban community of Pasquo, at an intersection with Tennessee State Route 100. In addition to Natchez and Nashville, larger cities along the route include Jackson and Tupelo, Mississippi, and Florence, Alabama.

A National Parkway is a designation for a protected area in the United States given to scenic roadways with a protected corridor of surrounding parkland. National Parkways often connect cultural or historic sites. The U.S. National Park Service manages the parkways.