This is a list of properties and historic districts in Missouri on the National Register of Historic Places. There are NRHP listings in all of Missouri's 114 counties and the one independent city of St. Louis.

Mexico, formerly known as New Mexico, is a city in and the county seat of Audrain County, Missouri. It is home to the Missouri Military Academy and annually hosts the Miss Missouri Pageant. The city's population was 11,469 at the 2020 census. The micropolitan statistical area consists of Audrain County. It is a part of the Columbia, Missouri metropolitan area.