National University (NU), colloquially National U, is a private non–sectarian coeducational university located in Sampaloc, Manila, Philippines. The founder of the university, Mariano F. Jhocson Sr., established the institution on August 1, 1900, as Colegio Filipino in Quiapo, Manila. It is considered as the first private nonsectarian and coeducational institution in the Philippines and also, the first university to use English as its medium of instruction, replacing Spanish.

Sampaloc is a district of Manila, Philippines. It is referred to as the University Belt or simply called "U-Belt" for numerous colleges and universities are found within the district such as the University of Santo Tomas, the oldest extant university in Asia; the National University, the first private nonsectarian and coeducational institution in the Philippines; the Far Eastern University, known for its Art Deco campus and cultural heritage site of the Philippines; and the University of the East, once dubbed as the largest university in Asia in terms of enrollment. The district is bordered by the districts of Quiapo and San Miguel in the south, Santa Mesa district in the south and east, Santa Cruz district in the west and north, and Quezon City in the northeast.