Navoiy Region is one of the regions of Uzbekistan. It is located in the central north/northwest of the country. It covers an area of 111,095 km2 (42,894 sq mi), which makes it the largest of the regions of Uzbekistan. The Navoiy region borders with Kazakhstan, Samarqand Region, Buxoro Region, Jizzakh Region, and the Karakalpakstan Republic. The population is estimated 1,033,857 (2022), with 51% living in rural areas. The capital is Navoiy. The region and its capital are named after the poet Ali-Shir Nava'i.

Samarqand Region is the most populous region of Uzbekistan. It is located in the center of the country in the basin of the Zarafshan River. It borders Tajikistan, Navoiy Region, Jizzakh Region and Qashqadaryo Region. It covers an area of 16,773 km2. The population is estimated to be around 4,031,324, with some 63% living in rural areas (2022).