Navojoa is the fifth-largest city in the northern Mexican state of Sonora and is situated in the southern part of the state. The city is the administrative seat of Navojoa Municipality, located in the Mayo River Valley.

Sonora, officially Estado Libre y Soberano de Sonora, is one of the 31 states which, along with Mexico City, comprise the Federal Entities of Mexico. The state is divided into 72 municipalities; the capital city of which being Hermosillo, located in the center of the state. Other large cities include Ciudad Obregón, Nogales, San Luis Río Colorado, and Navojoa.