The Necker–Enfants Malades Hospital is a French teaching hospital in the 15th arrondissement of Paris. It is a hospital of the Assistance Publique – Hôpitaux de Paris group and is affiliated to the Université Paris Cité. Necker–Enfants Malades Hospital was created in 1920 by the merger of Necker Hospital, which was founded in 1778 by Suzanne Necker, with the physically contiguous Sick Children's Hospital, the oldest children's hospital in the Western world, founded in 1801.

The 15th arrondissement of Paris is one of the 20 arrondissements of the capital city of France. In spoken French, it is referred to as le quinzième.