Nescopeck is a borough in Luzerne County, Pennsylvania, United States. The population was 1,480 as of the 2020 census.

Nescopeck Creek is a 37.5-mile-long (60.4 km) tributary of the Susquehanna River in Luzerne County, Pennsylvania. The creek is in the Coal Region of Pennsylvania. The meaning of the creek's name is "deep black waters". The waters of Nescopeck Creek have difficulty ratings between Class I and Class III. However, during parts of the year, Nescopeck Creek is impossible to navigate due to rapids, flooding, and tight bends. Nescopeck Creek is home to a number of species of trout, although the waters are not always optimal for them. Nescopeck Creek's water is acidic, with a pH as low as 3.6 in some studies.