Nespelem is a town in Okanogan County, Washington, United States. The population was 180 at the 2020 census. The town is located on the Colville Indian Reservation. The name Nespelem is derived from a local Native American term meaning "large flat meadow".

Okanogan County is a county located in the U.S. state of Washington along the Canada–U.S. border. As of the 2020 census, the population was 42,104. The county seat is Okanogan, while the largest city is Omak. Its area is the largest in the state.