Ness Ziona is a city in Central District, Israel. In 2022 it had a population of 50,341, and its jurisdiction was 15,579 dunams (15.579 km2 [6.015 sq mi]).

The Central District of Israel is one of six administrative districts, including most of the Sharon region. It is further divided into four sub-districts: Petah Tikva, Ramla, Sharon, and Rehovot. The district's largest city is Rishon LeZion. The district's population as of 2017 was 2,115,800. According to the Israeli Central Bureau of Statistics, 88% of the population is Jewish, 8.2% is Arab, and 4% are "non-classified", being mostly former Soviet Union immigrants of partial or nominal Jewish ethnic heritage or household members of Jews.