Neulußheim is the only station in the municipality of Neulußheim in the German state of Baden-Württemberg. It was re-built during the construction of the Mannheim–Stuttgart high-speed railway in 1986. It lies on the Rhine Railway and is classified by Deutsche Bahn (DB) as a category 5 station. Trains on the Mannheim–Stuttgart high-speed railway run next to the station without stopping.

The Mannheim–Stuttgart high-speed railway is a 99 km (62 mi) long railway line in Germany, connecting the cities of Mannheim and Stuttgart. The line was officially opened on 9 May 1991, and Intercity-Express service began on 2 June. The Hanover–Würzburg high-speed railway also opened at the same time. The line cost about DM 4.5 billion to build and has 15 tunnels and more than 90 bridges.