Neuromuscular-blocking drug
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Neuromuscular-blocking drugs, or Neuromuscular blocking agents, block transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. This is accomplished via their act
Fig.3 A simple illustration of how vecuronium binds to the nicotinic receptor. Its D-ring binds to the receptor at two points and the lipophillic side of the molecule repels cations from flowing through the ion-channel
Curare
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Curare is a common name for various alkaloid arrow poisons originating from plant extracts. Used as a paralyzing agent by indigenous peoples in Central and South America for hunting and for therapeuti
Neuromuscular-blocking drug
…common agents that act as competitive antagonists against acetylcholine at the site of postsynaptic acetylcholine receptors. Tubocurarine, found in curare of the South American plant Pareira, Chondrodendron tomentosum, is the prototypical non-depolarizing neuromuscular blocker. It has a slow onset (<5…
Chondrodendron tomentosum, the main source of 'tube curare' and principal source of D-tubocurarine (DTC), the alkaloid constituting medicinal curare
Strychnos toxifera, the Strychnos species which is the principal source of 'calabash curare' and its main active constituent, the alkaloid toxiferine
Curare darts and quiver from the Amazon rainforest
19th century depiction of hunting with blowguns in the Amazon rainforest