Neuromuscular-blocking drug
Videos
Neuromuscular-blocking drugs, or Neuromuscular blocking agents, block transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. This is accomplished via their act
Fig.3 A simple illustration of how vecuronium binds to the nicotinic receptor. Its D-ring binds to the receptor at two points and the lipophillic side of the molecule repels cations from flowing through the ion-channel
End-plate potential
Videos
End plate potentials are the voltages which cause depolarization of skeletal muscle fibers caused by neurotransmitters binding to the postsynaptic membrane in the neuromuscular junction. They are call
A sample endplate potential (EPP; an average of 10 single EPPs) is shown at the top, and sample miniature endplate potentials (mEPPs) are shown at the bottom. Note the differences in the scales on the X- and Y-axes. Both are taken from recordings at the mouse neuromuscular junction.
Signal transmission from nerve to muscle at the motor end plate.
Patient with myasthenia gravis showing typical symptom of eyelid droop