The New Bank of Santa Fe is the most important financial entity in the Santa Fe Province, Argentina and has the largest territorial coverage that reaches 96 percent of the district's inhabitants. It is a commercial bank with national and regional capital (finance). It has the central house located in the capital city of the province and its administrative headquarters in Rosario, Argentina.

The Province of Santa Fe is a province of Argentina, located in the center-east of the country. Neighboring provinces are from the north clockwise Chaco, Corrientes, Entre Ríos, Buenos Aires, Córdoba, and Santiago del Estero. Together with Córdoba and Entre Ríos, the province is part of the economico-political association known as the Center Region.