The New Delhi–Chennai main line is a railway line connecting Chennai and Delhi cutting across southern part of the Eastern Coastal Plains of India, the Eastern Ghats, the Deccan Plateau and the Yamuna valley. It covers a distance of 2,182 kilometres (1,356 mi) across Delhi, Haryana, Uttar Pradesh, Rajasthan, Madhya Pradesh, Maharashtra, Telangana, Andhra Pradesh and Tamil Nadu. The route is used by the Grand Trunk Express and as such is referred to by many as the Grand Trunk Route.

Vijayawada Junction Railway Station is an Indian Railways station in Vijayawada of Andhra Pradesh, categorized as a Non-Suburban Grade-2 (NSG-2) station in Vijayawada railway division. Situated at the junction of Howrah–Chennai and New Delhi–Chennai main lines, it is the fourth busiest railway station in the country after Howrah Junction, Kanpur Central and New Delhi. The station serves about 1.40 lakh passengers, over 190 express and 170 freight trains every day. It is one of the major railway junctions of the Indian Railways and is a nationally important halt. In September, 2023 It has been awarded Platinum Rating Certificate for its Environmental projects from IGBC