Grand Chain is a village in Pulaski County, Illinois, United States. The population was 190 at the 2010 census. The village's official name changed from "Grand Chain" to "New Grand Chain" in the 1970s, but its residents continue to refer to it as "Grand Chain."

Pulaski County is a county located in the U.S. state of Illinois. According to the 2020 census, it had a population of 5,193. Its county seat is Mound City. Its largest city is Mounds. It is located along the Ohio River in the southwestern portion of the state, known locally as "Little Egypt".