The New Haven–Springfield Line is a railroad line owned by Amtrak from New Haven, Connecticut, north to Springfield, Massachusetts, serving the Knowledge Corridor. As a branch of the Northeast Corridor just north of New Haven State Street station, it is served by approximately seven daily Northeast Regional round trips, some continuing from New Haven to Washington, D.C., along the Corridor and others terminating at New Haven as shuttles. On weekends, there is one train daily to Roanoke, Virginia. It is also served by the daily Vermonter, which starts in Washington, D.C., and continues north from Springfield, finally terminating in St. Albans, Vermont. The line is part of the Inland Route connecting Boston and New York via Hartford, Springfield, and Worcester, in contrast to the "Shore Line" along the Connecticut Shore and through Rhode Island.

The greater Hartford–Springfield area is an urban region and surrounding suburban areas that encompasses both north-central Connecticut and the southern Connecticut River Valley in western Massachusetts; its major city centers are Springfield, Massachusetts and Hartford, Connecticut.