Route 35 is a state highway in the U.S. state of New Jersey, primarily traveling through the easternmost parts of Middlesex, Monmouth, and Ocean counties. It runs 58.11 mi (93.52 km) from the entrance to Island Beach State Park in Berkeley Township, Ocean County to an intersection with Route 27 in Rahway, Union County. Between Seaside Park and Mantoloking, Route 35 follows the right-of-way of the former Pennsylvania Railroad along the Jersey Shore. The route heads through Point Pleasant Beach and crosses the Manasquan River on the Brielle Bridge, meeting Route 34 and Route 70 at the former Brielle Circle in Wall Township. From there, Route 35 heads north and intersects Route 138, an extension of Interstate 195, continuing north through Monmouth County before crossing the Victory Bridge over the Raritan River into Perth Amboy, where the route continues north to Rahway.

Middlesex County is located in the north-central part of the U.S. state of New Jersey, extending inland from the Raritan Valley region to the northern portion of the Jersey Shore. As of the 2020 United States census, the county was the state's third-most populous county with a population of 863,162, its highest decennial count ever and an increase of 53,304 (+6.6%) from the 2010 census count of 809,858, which in turn reflected an increase of 59,696 (8.0%) from the 750,162 counted in the 2000 census. Middlesex is part of the New York metropolitan area. Many communities within the county serve as commuter towns to and from New York City and other points north. The county is part of the Central Jersey region of the state.