Route 42 is a state highway in the U.S. state of New Jersey within the Camden area. It runs 14.28 mi (22.98 km) from an intersection with U.S. Route 322 and County Route 536 Spur in Monroe Township, Gloucester County, to an intersection with Interstate 76 (I-76) and I-295 in Bellmawr, Camden County. The southern portion of Route 42 is an four-lane divided highway and one of several highways comprising the Black Horse Pike, a road that runs from Camden to Atlantic City. The northern portion is part of a six- to eight-lane freeway referred to locally as the North–South Freeway that connects the Atlantic City Expressway to the Benjamin Franklin Bridge. Major junctions along the route include the Atlantic City Expressway and the southern terminus of Route 168 in Turnersville, Route 168 in Blackwood, and Route 41 and Route 55 in Deptford Township.

U.S. Route 322 is a spur of U.S. Route 22, running from Cleveland, Ohio, east to Atlantic City, New Jersey. The easternmost segment of the route in New Jersey runs 62.64 miles (100.81 km) from the Commodore Barry Bridge over the Delaware River in Logan Township, Gloucester County, where it continues southeast to Atlantic Avenue and Pacific Avenue in Atlantic City, Atlantic County. The portion of the route between the Commodore Barry Bridge and Route 42 in Williamstown is mostly a two-lane undivided road that is concurrently signed with County Route 536 (CR 536), passing through Mullica Hill and Glassboro. From Williamstown, US 322 follows the Black Horse Pike, a four-lane road, southeast to Atlantic City. In Hamilton Township, Atlantic County, US 322 forms a concurrency with U.S. Route 40, continuing with that route all the way to Atlantic City. US 322 intersects several major roads including U.S. Route 130 and Interstate 295 (I-295) in Logan Township, the New Jersey Turnpike in Woolwich Township, Route 55 in Harrison Township, Route 42 in Williamstown, Route 50 and U.S. Route 40 in Hamilton Township, the Garden State Parkway in Egg Harbor Township, and U.S. Route 9 in Pleasantville.