Route 48 is an east–west state highway in Salem County in the U.S. state of New Jersey. It is a 4.26-mile (6.86 km) route running from U.S. Route 130 and County Route 675 in Penns Grove southeast to US 40 in Carneys Point Township. It is known as East Main Street from US 130 to DuPont Road, and as the Harding Highway from DuPont Road to its terminus at US 40. Route 48 is signed east–west, although it travels more northwest-southeast throughout its route. It is a two-lane, undivided road through its entire length that intersects with Interstate 295 (I-295) and CR 551.

U.S. Route 40 is a U.S. highway running from Silver Summit, Utah east to Atlantic City, New Jersey. The easternmost segment of the route runs 64.32 miles (103.51 km) through the southern part of New Jersey between the Delaware Memorial Bridge over the Delaware River in Pennsville Township, Salem County, where it continues into Delaware along with Interstate 295 (I-295), east to Atlantic Avenue and Pacific Avenue in Atlantic City, Atlantic County. The route passes through Salem, Gloucester, and Atlantic counties as well as the boroughs of Woodstown, Elmer, Newfield, and Buena. The route encounters a mix of rural, suburban, and urban environs throughout its journey across South Jersey.