Route 49 is a state highway in the southern part of the U.S. state of New Jersey. It runs 53.80 mi (86.58 km) from an interchange with the New Jersey Turnpike, Interstate 295 (I-295), and U.S. Route 40 (US 40) in Deepwater, Salem County, southeast to Route 50 and County Route 557 in Tuckahoe, Cape May County. The route serves Salem, Cumberland, Atlantic, and Cape May counties, passing through rural areas and the communities of Salem, Bridgeton, and Millville along the way. It is a two-lane, undivided road for most of its length.

The New Jersey Turnpike (NJTP) is a system of controlled-access highways in the U.S. state of New Jersey. The turnpike is maintained by the New Jersey Turnpike Authority (NJTA). The 117.20-mile (188.62 km) mainline's southern terminus is at a complex interchange with Interstate 295 (I-295), U.S. Route 40 (US 40), US 130, and Route 49 near the border of Pennsville and Carneys Point townships in Salem County, one mile (1.6 km) east of the Delaware Memorial Bridge. Its northern terminus is at an interchange with I-80 and US 46 in Ridgefield Park. Construction of the mainline from concept to completion took 22 months, from 1950 to 1951. It was opened to traffic on November 5, 1951, between its southern terminus and exit 10.