New Orleans blues is a subgenre of blues that developed in and around the city of New Orleans, influenced by jazz and Caribbean music. It is dominated by piano and saxophone, but also produced guitar bluesmen.

Henry Roeland "Roy" Byrd, better known as Professor Longhair or "Fess" for short, was an American singer and pianist who performed New Orleans blues. He was active in two distinct periods, first in the heyday of early rhythm and blues and later in the resurgence of interest in traditional jazz after the founding of the New Orleans Jazz and Heritage Festival in 1970. His piano style has been described as "instantly recognizable, combining rumba, mambo, and calypso".