The New York State Psychiatric Institute, located at the Columbia University Irving Medical Center in the Washington Heights neighborhood of Manhattan, New York City, was established in 1895 as one of the first institutions in the United States to integrate teaching, research and therapeutic approaches to the care of patients with mental illnesses. In 1925, the Institute affiliated with Presbyterian Hospital, now NewYork-Presbyterian Hospital, adding general hospital facilities to the institute's psychiatric services and research laboratories.

Columbia University Irving Medical Center (CUIMC) is an academic medical center and the largest campus of NewYork-Presbyterian Hospital. It includes Columbia University Vagelos College of Physicians and Surgeons, College of Dental Medicine, School of Nursing and Mailman School of Public Health, as well as the Morgan Stanley Children's Hospital, the New York State Psychiatric Institute, the Audubon Biomedical Research Park, and other institutions.