New York State Route 22 (NY 22) is a north–south state highway that parallels the eastern border of the U.S. state of New York, from the outskirts of New York City to the hamlet of Mooers in Clinton County near the Canadian border. At 337 miles (542 km), it is the state's longest north–south route and the third longest state route overall, after NY 5 and NY 17. Many of the state's major east–west roads intersect with, and often join, NY 22 just before crossing into the neighboring New England states, where U.S. Route 7 (US 7), which originally partially followed NY 22's alignment, similarly parallels the New York state line.

Mooers, formerly Mooers-upon-the-Chazy, is a hamlet and census-designated place in the town of Mooers, in Clinton County, New York, United States. The population was 442 at the 2010 census, out of a total population of 3,592 in the town. It was once an incorporated village, but dissolved in 1994.