New York State Route 245 (NY 245) is a state highway in the Finger Lakes region of New York in the United States. The southern terminus of the route is at NY 21 in Naples. The northern terminus is at NY 5, U.S. Route 20 and NY 14A west of Geneva. From Geneva to Naples, NY 245 traverses the land from the north end of Seneca Lake to the south end of Canandaigua Lake in roughly a northeast to southwest direction.

New York State Route 21 (NY 21) is a state highway extending for about one hundred miles (160.9 km) through the western part of New York in the United States. The southern terminus of the route is at an intersection with NY 417 in the village of Andover, and its northern terminus is at a junction with NY 104 in the town of Williamson. In between, NY 21 serves the cities of Hornell and Canandaigua and intersects several major east–west routes, including the Southern Tier Expressway near Hornell, the conjoined routes of U.S. Route 20 (US 20) and NY 5 in Canandaigua, the New York State Thruway (I-90) in Manchester, and NY 31 in Palmyra.