New York State Route 26 (NY 26) is a north–south state highway that runs for 203.80 miles (327.98 km) through Central New York in the United States. Its southern terminus is located at the Pennsylvania state line south of the town of Vestal in Broome County, where it becomes Pennsylvania Route 267 (PA 267). Its northern terminus is located at a junction with NY 12 in the village of Alexandria Bay in Jefferson County. NY 26 serves three cities along its routing; one directly (Rome) and two via other roadways. NY 26 also intersects several other primary routes including I-81 in Barker, an overlap with U.S. Route 20 (US 20) in Madison, NY 12 in Lowville, and an overlap with US 11 in the Jefferson County town of Philadelphia.

Vestal is a town within Broome County in the Southern Tier of New York, United States, and lies between the Susquehanna River and the Pennsylvania border. As of the 2020 census, the population was 29,110. Vestal is on the southern border of the county, and serves as a western suburb of the city of Binghamton. The town is home to the main campus of Binghamton University.