New York State Route 365 (NY 365) is an east–west state highway in the central portion of New York, United States. It extends for 44.26 miles (71.23 km) from an intersection with NY 5, east of the Madison County city of Oneida to a junction with NY 8 in the Herkimer County town of Ohio. The portion of NY 365 in western and central Oneida County is a regionally important highway that serves densely populated areas, including the cities of Oneida and Rome. In Verona, a town situated midway between the two locations, NY 365 passes by the Turning Stone Resort & Casino and connects to the New York State Thruway. East of Barneveld, a village in eastern Oneida County, NY 365 is a rural connector road that runs along the Hinckley Reservoir, a waterbody that extends into Herkimer County and Adirondack Park.

New York State Route 5 (NY 5) is a state highway that extends for 370.80 miles (596.74 km) across the state of New York in the United States. It begins at the Pennsylvania state line in the Chautauqua County town of Ripley and passes through Buffalo, Syracuse, Utica, Schenectady, and several other smaller cities and communities on its way to downtown Albany in Albany County, where it terminates at U.S. Route 9 (US 9), here routed along the service roads for Interstate 787 (I-787). Prior to the construction of the New York State Thruway, it was one of two main east–west highways traversing upstate New York, the other being US 20. West of New York, the road continues as Pennsylvania Route 5 (PA 5) to Erie.