New York State Route 376 (NY 376) is a state highway located entirely within Dutchess County in the Hudson Valley region of New York in the United States. The route begins at an intersection with NY 52 in East Fishkill and passes north through Hopewell Junction and Red Oaks Mill on its way to the city of Poughkeepsie. It ends at a junction with U.S. Route 44 (US 44) and NY 55 east of the city limits in Arlington, a hamlet in the town of Poughkeepsie. NY 376 was originally designated as part of NY 39 in the mid-1920s. In the 1930 renumbering of state highways in New York, the East Fishkill–Poughkeepsie portion of NY 39 was renumbered to New York State Route 202. NY 202 was renumbered to NY 376 in 1935 to avoid numerical duplication with the new US 202.

New York State Route 52 (NY 52) is a 108.72-mile-long (174.97 km) state highway in the southeastern part of the state. It generally runs from west to east through five counties, beginning at the Pennsylvania state line in the Delaware River near Narrowsburg, crossing the Hudson River on the Newburgh–Beacon Bridge, and ending in Carmel. NY 52 and NY 55, both major east–west routes of the Mid-Hudson Region, run parallel to each other, intersecting in downtown Liberty.