New York State Route 46 (NY 46) is a state highway in Central New York in the United States. It extends from NY 12B in the Madison County town of Eaton to NY 12D in the Oneida County village of Boonville. NY 46 passes through the cities of Oneida and Rome.

New York State Route 12B (NY 12B) is a state highway in the central part of New York in the United States. NY 12B is a north–south highway connecting Oneida County in the north to Chenango County in the south, passing through Madison County in between. The southern terminus of NY 12B is at NY 12 in the village of Sherburne. The northern terminus is at NY 5 in the town of New Hartford. In Madison County, NY 12B directly abuts the campus of Colgate University in the village of Hamilton.