New York State Route 5S (NY 5S) is a 72.92-mile-long (117.35 km) east–west state highway located in the Mohawk Valley of New York in the United States. It extends from a continuation of NY 5A at an interchange with I-790, NY 5, NY 8, and NY 12 in Utica to an interchange with I-890 and NY 890 in Rotterdam. The route runs along the south side of the Mohawk River for its entire length and parallels NY 5, which runs along the north side of the Mohawk River. NY 5S intersects several primary routes including NY 28 in Mohawk, NY 30A in Fultonville, NY 30 south of Amsterdam, as well as intersecting the New York State Thruway (I-90) several times. The route is part of New York State Bicycle Route 5 west of its junction with NY 103 in Schenectady County.

New York State Route 5A (NY 5A) is an east–west state highway located within Oneida County, New York, in the United States. It is a 5.59-mile (9.0 km) alternate route of NY 5 between New Hartford and downtown Utica. At its eastern end, NY 5A becomes NY 5S at an interchange with Interstate 790 (I-790), NY 5, NY 8, and NY 12. The route is four lanes wide and passes through mostly commercial areas. When NY 5A was assigned in the mid-1930s, it ended at Yorkville, a village roughly midway between NY 5 in New Hartford and downtown Utica. It was extended to its present length in the 1940s.