New York State Route 80 (NY 80) is a 127.32-mile-long (204.90 km) west–east New York State Route located within Onondaga, Madison, Chenango, Otsego, Herkimer, and Montgomery counties in New York. Its western terminus is located at a junction with NY 175 in the city of Syracuse in Onondaga County, from which it actually runs in a north–south direction for 20 miles (32 km). The eastern terminus is located at a junction with NY 5 in the village of Nelliston in Montgomery County. The route is signed north–south from U.S. Route 20 (US 20) north to NY 5.

Sherburne is a village in Chenango County, New York, United States. The population was 1,367 at the 2010 census. It is in the town of Sherburne, north of Norwich.