Newbern Depot, also known as Newbern Illinois Central Depot or as the Newbern–Dyersburg station, is an Amtrak station and museum in Newbern, Tennessee. It is an unstaffed flag stop on the City of New Orleans route, which serves Newbern and nearby Dyersburg when passengers have tickets to and from the station. The building was constructed by Illinois Central Railroad in 1920 and was added to the National Register of Historic Places in 1993.

Dyersburg is a city and the county seat of Dyer County, Tennessee, United States. It is located in northwest Tennessee, 79 miles (127 km) northeast of Memphis on the Forked Deer River. The population was 16,164 at the 2020 census, down 5.72% from the 2010 census.