Newberry is a city in Newberry County, South Carolina, United States, in the Piedmont 43 miles northwest of Columbia. The charter was adopted in 1894. The population was 10,277 at the 2010 census. It is the county seat of Newberry County; at one time it was called Newberry Courthouse.

Newberry County is a county located in the U.S. state of South Carolina. As of the 2020 census, its population was 37,719. Its county seat is Newberry. The name is of unknown origin, although one theory suggests that it was named by Quaker settlers in honor of their home of Newberry, a suburb of London in the United Kingdom.