Niš Constantine the Great Airport, located 4 km (2.5 mi) northwest of downtown Niš, in the suburbs of Medoševac and Popovac. It is the second-largest and second-busiest airport in Serbia, after Belgrade Nikola Tesla Airport. Niš Military Air Base, the Serbian-Russian Emergency Response Centre and Centre for Aerial Firefighting Duties are all located on the site of the airport.

Niš, less often spelled in English as Nish, is the third largest city in Serbia and the administrative center of the Nišava District. It is located in the southern part of Serbia. According to the 2011 census, the city proper has a population of 182,797, while its administrative area has a population of 260,237 inhabitants.