The Nicholas U. Mayall Telescope, also known as the Mayall 4-meter Telescope, is a four-meter reflector telescope located at the Kitt Peak National Observatory in Arizona and named after Nicholas U. Mayall. It saw first light on February 27, 1973, and was the second-largest telescope in the world at that time. Initial observers included David Crawford, Nicholas Mayall, and Arthur Hoag. It was dedicated on June 20, 1973 after Mayall's retirement as director. The mirror has an f/2.7 hyperboloidal shape. It is made from a two-foot thick fused quartz disk that is supported in an advanced-design mirror cell. The prime focus has a field of view six times larger than that of the Hale reflector. It is host to the Dark Energy Spectroscopic Instrument. The identical Víctor M. Blanco Telescope was later built at Cerro Tololo Inter-American Observatory, in Chile.

The Kitt Peak National Observatory (KPNO) is a United States astronomical observatory located on Kitt Peak of the Quinlan Mountains in the Arizona-Sonoran Desert on the Tohono Oʼodham Nation, 88 kilometers (55 mi) west-southwest of Tucson, Arizona. With more than twenty optical and two radio telescopes, it is one of the largest gatherings of astronomical instruments in the Earth's northern hemisphere.