Nickelsville is a town in Scott County, Virginia. The population was 378 at the 2020 census. It is part of the Metropolitan Statistical Area, which is a component of the Johnson City-Kingsport-Bristol, TN-VA Combined Statistical Area – commonly known as the "Tri-Cities" region.

Scott County is a county located in the far southwestern part of the U.S. state of Virginia, on the border with Tennessee. As of the 2020 census, the population was 21,576. Its county seat is Gate City. Scott County was formed by an act of the General Assembly on November 24, 1814, from parts of Washington, Lee, and Russell counties and was named for Virginia -born General Winfield Scott. Scott County is part of the Kingsport–Bristol–Bristol, TN-VA Metropolitan Statistical Area, which is a component of the Johnson City–Kingsport–Bristol, TN-VA Combined Statistical Area, commonly known as the "Tri-Cities" region. The County Administrator is Freda Russell Starnes.