Nicolás Fernández de Córdoba y de la Cerda, 10th Duke of Medinaceli, GE was a Spanish aristocrat. He was the 10th Duke of Medinaceli, an Ambassador of the King of Spain, Majordomo and Stable master of the queen, and a knight of the Order of the Golden Fleece.

Duke of Medinaceli is an hereditary title in the peerage of Spain, accompanied by the dignity of Grandee. The Catholic Monarchs, Ferdinand II of Aragon and Isabella I of Castile, created the title and awarded it on 31 October 1479 to Luis de la Cerda y de la Vega. He also held the title of 5th Count of Medinaceli, which was first awarded in 1368 to his ancestor, Bernal de Foix.