Nicolas de Besse was born in the diocese of Limoges, in 1322. He was a French bishop and Cardinal. He was the son of Jacques de Besse, Seigneur de Bellefaye and Almodie (Delphine) Roger, sister of Pope Clement VI. He had a brother Pierre de Besse, who became Seigneur de Bellefaye and who married Margueritte de Thiers. Nicolas de Besse died in Rome on 5 November 1369.

Pope Clement VI, born Pierre Roger, was head of the Catholic Church from 7 May 1342 to his death, in December 1352. He was the fourth Avignon pope. Clement reigned during the first visitation of the Black Death (1348–1350), during which he granted remission of sins to all who died of the plague.