The 2011 Night of Champions was the fifth annual Night of Champions professional wrestling pay-per-view (PPV) event produced by WWE. It took place on September 18, 2011, at the First Niagara Center in Buffalo, New York. It was WWE's first PPV event to be held following the dissolution of the original brand extension. The concept of the show was that every championship in the company at the time was defended.

KeyBank Center is a multipurpose indoor arena located in Buffalo, New York. Originally known as Marine Midland Arena, the venue has since been named HSBC Arena and First Niagara Center. Home to the Buffalo Sabres of the National Hockey League since 1996, is the largest indoor arena in Western New York, seating 19,070. It replaced the Sabres' former home, Buffalo Memorial Auditorium, where the team played from 1970 to 1996. The venue is also home to the Buffalo Bandits of the National Lacrosse League.