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Night of the Living Dead

Night of the Living Dead is a 1968 American independent horror film written, directed and edited by George A. Romero, co-written by John Russo, starring Duane Jones and Judith O'Dea; the story follows seven people who are trapped in a rural farmhouse in western Pennsylvania, under assault by an enlargening group of cannibalistic, undead corpses. The film was completed on a US$114,000 budget and shot outside Pittsburgh, where it had its theatrical premiere on October 1, 1968; the film grossed US$12 million domestically and US$18 million internationally, earning more than 250 times its budget. Night of the Living Dead has been regarded as a cult classic by film scholars and critics, despite being criticized upon its release for its explicit gore, it garnered critical acclaim and was selected in 1999 by the Library of Congress for preservation in the National Film Registry as a film deemed "culturally or aesthetically significant". Night of the Living Dead led to five subsequent films between 1978 and 2009 directed by Romero, inspired several remakes.

In 2019, the German Commission for Youth Protection requested the film be taken down from the German version of Netflix, the company complied. Siblings Barbara and Johnny drive to a rural Pennsylvania cemetery to visit their father's grave. In the cemetery, a strange man kills Johnny and viciously attacks Barbara as she attempts to take shelter in a distant farmhouse. After discovering the farmhouse resident half-eaten, she sees a multiplying number of strange ghouls led by the man in the cemetery. A man named Ben drives away the ghouls, he finds a lever-action-rifle and discovers the ghouls can be driven away by fire. Throughout the night, Barbara gains shock in reaction to the situation. Barbara discovers the farmhouse has a cellar housing an angry couple and Helen Cooper, their daughter, who all sought refuge after a group of the same monsters overturned their car and bit Karen, leaving her ill. Tom and Judy, a teenage couple, arrive after hearing an emergency broadcast about a series of brutal killings.

Tom aids Ben in securing the farmhouse while Harry returns to the cellar. More ghouls besiege the farmhouse; the occupants of the house listen as radio and television reports explain a mass wave of murder is occurring on the East Coast of the United States by an army of cannibalistic, reanimating corpses, posses of armed men are patrolling the countryside to restore order. It reports a heavy blow to the head can stop the ghouls, that various rescue centers are offering refuge and safety; the reports explain most conclude to one possible theory from a scientist that the reanimations are due to a space probe's radiation that exploded in Earth's atmosphere while returning from Venus. Ben devises a plan to obtain medical supplies for Karen and transport the group to a rescue center by refueling his truck. Ben and Judy drive to a nearby gas pump with the ghouls in pursuit. However, the truck catches on fire with Ben's torch, after Tom and Judy are locked inside, they're incinerated and devoured by the ghouls.

Ben beats Harry for nearly locking him outside in cowardice, the remaining survivors attempt to find a way out. However, the ghouls break through the barricades. Ben manages to take refuge in the cellar where he shoots Harry and Helen's reanimating bodies as the ghouls fail to break in upstairs; the next morning, Ben is mistaken for a ghoul and is killed with a gunshot to the head from the posse. He is burned with the rest of the ghouls. Duane Jones as Ben: An unknown stage actor, Jones' performance depicted Ben as a "comparatively calm and resourceful Negro", according to a movie reviewer in 1969. Casting Jones as the hero was controversial in 1968: it was not typical for a black man to be the hero of an American film when the rest of the cast was composed of white actors, but Romero said that Jones gave the best audition, he was in other films after Night of the Living Dead such as Ganja & Hess and Beat Street and continued working as a theater actor and director until his death in 1988. Despite his other film roles, Jones worried.

Judith O'Dea as Barbara: A 23-year-old commercial and stage actress, O'Dea once worked for Hardman and Eastman in Pittsburgh. O'Dea was in Hollywood seeking to enter the movie business at the time of audition. Starring in the film was a positive experience for her, she remarked in an interview, she admitted that horror movies terrified her Vincent Price's House of Wax. In addition to acting, O'Dea performed her own stunts, which she jokingly claimed amounted to "lots of running". Assessing Night of the Living Dead, she commented "I had no idea it would have such a lasting impact on our culture", she was just as surprised by the renown. Ho-hum Judy O'Dea until they realize Barbara from Night of the Living Dead. All of a sudden not so ho-hum anymore!" Karl Hardman as Harry Cooper: One of the film's producers (alongside

Circular permutation in proteins

A circular permutation is a relationship between proteins whereby the proteins have a changed order of amino acids in their peptide sequence. The result is a protein structure with different connectivity, but overall similar three-dimensional shape. In 1979, the first pair of circularly permuted proteins – concanavalin A and lectin – were discovered. Circular permutation can occur as the result of evolutionary events, posttranslational modifications, or artificially engineered mutations; the two main models proposed to explain the evolution of circularly permuted proteins are permutation by duplication and fission and fusion. Permutation by duplication occurs when a gene undergoes duplication to form a tandem repeat, before redundant sections of the protein are removed. Fission and fusion occurs when partial proteins fuse to form a single polypeptide, such as in nicotinamide nucleotide transhydrogenases. Circular permutations are engineered in the laboratory to improve their catalytic activity or thermostability, or to investigate properties of the original protein.

Traditional algorithms for sequence alignment and structure alignment are not able to detect circular permutations between proteins. New non-linear approaches have been developed that overcome this and are able to detect topology-independent similarities. In 1979, Bruce Cunningham and his colleagues discovered the first instance of a circularly permuted protein in nature. After determining the peptide sequence of the lectin protein favin, they noticed its similarity to a known protein – concanavalin A – except that the ends were circularly permuted. Work confirmed the circular permutation between the pair and showed that concanavalin A is permuted post-translationally through cleavage and an unusual protein ligation. After the discovery of a natural circularly permuted protein, researchers looked for a way to emulate this process. In 1983, David Goldenberg and Thomas Creighton were able to create a circularly permuted version of a protein by chemically ligating the termini to create a cyclic protein introducing new termini elsewhere using trypsin.

In 1989, Karolin Luger and her colleagues introduced a genetic method for making circular permutations by fragmenting and ligating DNA. This method allowed for permutations to be introduced at arbitrary sites. Despite the early discovery of post-translational circular permutations and the suggestion of a possible genetic mechanism for evolving circular permutants, it was not until 1995 that the first circularly permuted pair of genes were discovered. Saposins are a class of proteins involved in sphingolipid catabolism and antigen presentation of lipids in humans. Chris Ponting and Robert Russell identified a circularly permuted version of a saposin inserted into plant aspartic proteinase, which they nicknamed swaposin. Saposin and swaposin were the first known case of two natural genes related by a circular permutation. Hundreds of examples of protein pairs related by a circular permutation were subsequently discovered in nature or produced in the laboratory; as of February 2012, the Circular Permutation Database contains 2,238 circularly permuted protein pairs with known structures, many more are known without structures.

The CyBase database collects proteins that are cyclic, some of which are permuted variants of cyclic wild-type proteins. SISYPHUS is a database that contains a collection of hand-curated manual alignments of proteins with non-trivial relationships, several of which have circular permutations. There are two main models that are being used to explain the evolution of circularly permuted proteins: permutation by duplication and fission and fusion; the two models have compelling examples supporting them, but the relative contribution of each model in evolution is still under debate. Other, less common, mechanisms have been proposed, such as "cut and paste" or "exon shuffling"; the earliest model proposed for the evolution of circular permutations is the permutation by duplication mechanism. In this model, a precursor gene first undergoes a duplication and fusion to form a large tandem repeat. Next and stop codons are introduced at corresponding locations in the duplicated gene, removing redundant sections of the protein.

One surprising prediction of the permutation by duplication mechanism is that intermediate permutations can occur. For instance, the duplicated version of the protein should still be functional, since otherwise evolution would select against such proteins. Duplicated intermediates where only one terminus was truncated should be functional; such intermediates have been extensively documented in protein families such as DNA methyltransferases. An example for permutation by duplication is the relationship between swaposin. Saposins are conserved glycoproteins 80 amino acid residues long and forming a four alpha helical structure, they have a nearly identical placement of cysteine residues and glycosylation sites. The cDNA sequence, it is a precursor for four cleavage products, the saposins A, B, C, D. The four saposin domains most arose from two tandem duplications of an ancestral gene; this repeat suggests a mechanism for the evolution of the relationship with the plant-specific insert. The PSI is a domain found in plants, consisting of 100 residues and found in plant aspartic proteases.

It belongs to the saposin-like protein family and has the N- and C- termini "swapped", such that the order of helices is 3-4-1-2 compared with saposin, thus leading to the name "swaposin". Another model for the evolution of circular permutations is the fission and f

Umm al-Fahm bus bombing

The Umm al-Fahm bus bombing was a suicide bombing which occurred on March 20, 2002 on an Egged bus, passing through Umm al-Fahm in northern Israel. 7 people were killed in the attack and 27 people were injured. The Palestinian Islamist militant organization Islamic Jihad claimed responsibility for the attack. On Wednesday, 7:05 am March 20, 2002, a Palestinian militant exploded himself on Egged bus no. 823, traveling on Highway 65 on its way from Tel Aviv to Nazareth. The explosion occurred. Seven people - four soldiers and three civilians - were killed in the explosion and 27 other passengers were injured. Mogus Mahento, 65, of Holon Bella Schneider, 53, of Hadera Alon Goldenberg, 28, of Tel Aviv Aharon Revivo, 19, of Afula Shimon Edri, 20, of Pardes Hanna-Karkur Mikhael Altfiro, 19, of Pardes Hanna-Karkur Meir Fahima, 40, of Hadera The Palestinian Islamist militant organization Islamic Jihad which claimed responsibility for the attack stated that the suicide bomber was a 24-year-old Palestinian Rifat Abu-Ediak from Jenin.

Bus Blast Kills 7 In Israel - published on Kentucky New Era on 20 March 2002

Bae (surname)

Bae spelled Bai or Pae, is a Korean family name. The South Korean census of 2015 found 400,641 people by this surname, or less than 1% of the population. In a study by the National Institute of the Korean Language based on 2007 application data for South Korean passports, it was found that 96.8% of people with this family name spelled it in Latin letters as Bae. Rarer alternative spellings included Bai and Bea. There are two different ways to write the name in hanja: the most common, an alternative which lacks the "stem" at the top. A common question when people sharing this surname meet is, "Does your pear have a stem or not?", as the Korean word for "pear" is bae. The same character is used to write the Chinese surname Pei, is the origin of the Vietnamese surname Bùi. Bae Doona, South Korean model and actress Bae Eun-sik, South Korean actor who portrays Kim Jong-il Bae Hae-min, South Korean footballer Bae Jeong-min, South Korean voice actor Bae Jin-young, member of South Korean boy group WANNA ONE and former Produce 101 Season 02 contestant ZN, member of South Korean girl group Laboum Bae Jong-ok, South Korean actress Bae Ki-jong, South Korean footballer Bae Ki-sung, South Korean singer Bae Seul-ki, South Korean pop singer Bae Seong-woo, South Korean actor Bae Soo-bin, South Korean actor Bae Sung-jae, South Korean television personality Bae Suzy, South Korean actress and a former member of girl group Miss A Bae Sang-moon, South Korean professional golfer Bae Woo-hee, member of the South Korean girl group Dal Shabet Bae Yong-joon, South Korean actor Bae Yong-kyun, South Korean film director Bae Young-soo, South Korean baseball player Binnie, member of South Korean girl group OH MY GIRL Chae Soo-bin, South Korean actress Irene, member of South Korean girl group Red Velvet Jacob, member of South Korean boy group THE BOYZ Bae Seung-min, South Korean boy group Golden Child Pae Kil-su, North Korean gymnast Pae Tal-jun, high-ranking North Korean politician and bureaucrat Tak Jae-hoon, South Korean entertainer Bae Jin-young, South Korean singer and a member of South Korean boy group CIX Korean name List of people of Korean descent

American Ballet

The American Ballet was the first professional ballet company George Balanchine created in the United States. The company was founded with the help of Lincoln Kirstein and Edward Warburg, managed by Alexander Merovitch and populated by students of Kirstein and Balanchine's School of American Ballet. Having failed to mount a tour, American Ballet began performing at the "Old Met." After being allowed to stage only two dance performances, Balanchine moved the company to Hollywood in 1938. The company was restarted as the American Ballet Caravan and toured North and South America, although it too folded after several years. New York City Ballet Sunday NY Times, June 10, 1934 NY Times, June 11, 1934 Sunday NY Times, November 4, 1934 NY Times, February 7, 1935 NY Times, February 22, 1935 Sunday NY Times, John Martin, February 24, 1935 NY Times, August 8, 1935 NY Times, August 13, 1935 NY Times, August 20, 1935 Sunday NY Times, letter to the editor from Lincoln Kirstein, August 25, 1935 Sunday NY Times review of benefit for the Westchester County Girl Scouts at County Centre, September 29, 1935 NY Times by H. Howard Taubman, April 13, 1938

Doug Witcomb

Douglas Frederick "Doug" Witcomb was a former football player from Wales who played for the Welsh national team and for West Bromwich Albion, Sheffield Wednesday and Newport County in the English Football League. A wing-half, Witcomb started playing at Enfield before beginning his Football League career with West Bromwich Albion in 1937. In a war-interrupted time with the club, he scored 3 goals. In March 1947, he joined Sheffield Wednesday and made 224 Football League appearances for the club, scoring 12 goals, he made six FA Cup appearances for the side. He joined Newport County for the 1953–54 season in November 1953, making 25 appearances before joining Llandudno, he made one wartime appearance for Leicester City in 1941. He failed to score in a 3–0 defeat. Witcomb attained three caps for the Welsh national team, playing in all three of his country's matches in the 1946–47 British Home Championship, making his debut on 19 October 1946 in a 3–1 victory over Scotland. Wales lost 3 -- 0 to England and 2 -- 1 to Ireland.

He did not score any goals. He played seven wartime matches for Wales, scoring one goal