The Nightingale Pledge, named in honour of Florence Nightingale, is a modified version of the Hippocratic Oath. Lystra Gretter and a Committee for the Farrand Training School Grace for Nurses in Detroit, Michigan created the pledge in 1893. Gretter, inspired by the work of Nightingale, the founder of modern nursing, credited the pledge to the work of her committee, but was herself considered "the moving spirit behind the idea" for the pledge.

Florence Nightingale was an English social reformer, statistician and the founder of modern nursing. Nightingale came to prominence while serving as a manager and trainer of nurses during the Crimean War, in which she organised care for wounded soldiers at Constantinople. She significantly reduced death rates by improving hygiene and living standards. Nightingale gave nursing a favourable reputation and became an icon of Victorian culture, especially in the persona of "The Lady with the Lamp" making rounds of wounded soldiers at night.