Nikita Sergeyevich Khrushchev was First Secretary of the Communist Party of the Soviet Union from 1953 to 1964, and Chairman of the Council of Ministers (premier) from 1958 to 1964. During his rule, Khrushchev stunned the communist world with his denunciation of his predecessor Joseph Stalin's crimes and embarked on a policy of de-Stalinization with his key ally Anastas Mikoyan. He sponsored the early Soviet space program and the enactment of moderate reforms in domestic policy. After some false starts, and a narrowly avoided nuclear war over Cuba, he conducted successful negotiations with the United States to reduce Cold War tensions. In 1964, the Kremlin circle stripped him of power, replacing him with Leonid Brezhnev as First Secretary and Alexei Kosygin as Premier.

The General Secretary of the Central Committee of the Communist Party of the Soviet Union was the leader of the Communist Party of the Soviet Union (CPSU). From 1924 until the country's dissolution in 1991, the officeholder was the recognized leader of the Soviet Union. Prior to Stalin's accession, the position was not viewed as an important role in Lenin's government and previous occupants had been responsible for technical rather than political decisions.